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Dependency and false discovery rate: Asymptotics

Abstract

Some effort has been undertaken over the last decade to provide conditions for the control of the false discovery rate by the linear step-up procedure (LSU) for testing nn hypotheses when test statistics are dependent. In this paper we investigate the expected error rate (EER) and the false discovery rate (FDR) in some extreme parameter configurations when nn tends to infinity for test statistics being exchangeable under null hypotheses. All results are derived in terms of pp-values. In a general setup we present a series of results concerning the interrelation of Simes' rejection curve and the (limiting) empirical distribution function of the pp-values. Main objects under investigation are largest (limiting) crossing points between these functions, which play a key role in deriving explicit formulas for EER and FDR. As specific examples we investigate equi-correlated normal and tt-variables in more detail and compute the limiting EER and FDR theoretically and numerically. A surprising limit behavior occurs if these models tend to independence.

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