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Combining p-values via averaging

Abstract

This note discusses the problem of multiple testing of a single hypothesis, with a standard goal of combining a number of p-values without making any assumptions about their dependence structure. An old result by Rueschendorf shows that the p-values can be combined by scaling up their arithmetic mean by a factor of 2 (but no smaller factor is sufficient in general). More recent results in mathematical finance show, in addition, that KK p-values can be combined by scaling up their geometric mean by a factor of ee and by scaling up their harmonic mean by a factor of elnKe\ln K. This leads to a generalized version of the Bonferroni-Holm method.

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