Despite remarkable recent progress on both unconditional and conditional image synthesis, it remains a long-standing problem to learn generative models that are capable of synthesizing realistic and sharp images from reconfigurable spatial layout (i.e., bounding boxes + class labels in an image lattice) and style (i.e., structural and appearance variations encoded by latent vectors), especially at high resolution. By reconfigurable, it means that a model can preserve the intrinsic one-to-many mapping from a given layout to multiple plausible images with different styles, and is adaptive with respect to perturbations of a layout and style latent code. In this paper, we present a layout- and style-based architecture for generative adversarial networks (termed LostGANs) that can be trained end-to-end to generate images from reconfigurable layout and style. Inspired by the vanilla StyleGAN, the proposed LostGAN consists of two new components: (i) learning fine-grained mask maps in a weakly-supervised manner to bridge the gap between layouts and images, and (ii) learning object instance-specific layout-aware feature normalization (ISLA-Norm) in the generator to realize multi-object style generation. In experiments, the proposed method is tested on the COCO-Stuff dataset and the Visual Genome dataset with state-of-the-art performance obtained. The code and pretrained models are available at \url{https://github.com/iVMCL/LostGANs}.
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