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Efficient Inference of Nonparametric Interaction in Spiking-neuron Networks

23 June 2020
Feng Zhou
Yixuan Zhang
Jun Zhu
ArXiv (abs)PDFHTML
Abstract

Hawkes process provides an effective statistical framework for analyzing the time-dependent interaction of neuronal spiking activities. Although utilized in many real applications, the classical Hawkes process is incapable of modelling inhibitory interactions among neurons. Instead, the nonlinear Hawkes process allows for a more flexible influence pattern with excitatory or inhibitory interactions. In this paper, three sets of auxiliary latent variables (P\'{o}lya-Gamma variables, latent marked Poisson processes and sparsity variables) are augmented to make synapses connection weights in a Gaussian form, which allows for a simple iterative algorithm with analytical updates. As a result, an efficient expectation-maximization (EM) algorithm is derived to obtain the maximum a posteriori (MAP) estimate. We demonstrate the accuracy and efficiency performance of our algorithm on synthetic and real data. For real neural recordings, we show our algorithm can estimate the temporal dynamics of interaction and reveal the interpretable synaptic structure underlying neural spike trains.

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