We elucidate the problem of estimating large-dimensional covariance matrices in the presence of correlations between samples. To this end, we generalize the Marcenko-Pastur equation and the Ledoit-Peche shrinkage estimator using methods of random matrix theory and free probability. We develop an efficient algorithm that implements the corresponding analytic formulas, based on the Ledoit-Wolf kernel estimation technique. We also provide an associated open-source Python library, called "shrinkage", with a user-friendly API to assist in practical tasks of estimation of large covariance matrices. We present an example of its usage for synthetic data generated according to exponentially-decaying auto-correlations.
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