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KG-Hub -- Building and Exchanging Biological Knowledge Graphs

31 January 2023
J. H. Caufield
Timothy Putman
Kevin Schaper
Deepak R. Unni
Harshad B. Hegde
Tiffany J. Callahan
L. Cappelletti
Sierra A T Moxon
V. Ravanmehr
S. Carbon
L. Chan
Katherina G Cortes
Kent A. Shefchek
Glass Elsarboukh
James P Balhoff
Tommaso Fontana
N. A. Matentzoglu
R. Bruskiewich
A. Thessen
N. Harris
M. Munoz-Torres
M. Haendel
Peter N. Robinson
marcin p. joachimiak
Christopher J. Mungall
Justin P Reese
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Abstract

Knowledge graphs (KGs) are a powerful approach for integrating heterogeneous data and making inferences in biology and many other domains, but a coherent solution for constructing, exchanging, and facilitating the downstream use of knowledge graphs is lacking. Here we present KG-Hub, a platform that enables standardized construction, exchange, and reuse of knowledge graphs. Features include a simple, modular extract-transform-load (ETL) pattern for producing graphs compliant with Biolink Model (a high-level data model for standardizing biological data), easy integration of any OBO (Open Biological and Biomedical Ontologies) ontology, cached downloads of upstream data sources, versioned and automatically updated builds with stable URLs, web-browsable storage of KG artifacts on cloud infrastructure, and easy reuse of transformed subgraphs across projects. Current KG-Hub projects span use cases including COVID-19 research, drug repurposing, microbial-environmental interactions, and rare disease research. KG-Hub is equipped with tooling to easily analyze and manipulate knowledge graphs. KG-Hub is also tightly integrated with graph machine learning (ML) tools which allow automated graph machine learning, including node embeddings and training of models for link prediction and node classification.

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