In pathology, the rarity of certain diseases and the complexity in annotating pathological images significantly hinder the creation of extensive, high-quality datasets. This limitation impedes the progress of deep learning-assisted diagnostic systems in pathology. Consequently, it becomes imperative to devise a technology that can discern new disease categories from a minimal number of annotated examples. Such a technology would substantially advance deep learning models for rare diseases. Addressing this need, we introduce the Dual-channel Prototype Network (DCPN), rooted in the few-shot learning paradigm, to tackle the challenge of classifying pathological images with limited samples. DCPN augments the Pyramid Vision Transformer (PVT) framework for few-shot classification via self-supervised learning and integrates it with convolutional neural networks. This combination forms a dual-channel architecture that extracts multi-scale, highly precise pathological features. The approach enhances the versatility of prototype representations and elevates the efficacy of prototype networks in few-shot pathological image classification tasks. We evaluated DCPN using three publicly available pathological datasets, configuring small-sample classification tasks that mirror varying degrees of clinical scenario domain shifts. Our experimental findings robustly affirm DCPN's superiority in few-shot pathological image classification, particularly in tasks within the same domain, where it achieves the benchmarks of supervised learning.
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