Approaches to aligning large language models (LLMs) with human values has focused on correcting misalignment that emerges from pretraining. However, this focus overlooks another source of misalignment: bad actors might purposely fine-tune LLMs to achieve harmful goals. In this paper, we present an emerging threat model that has arisen from alignment circumvention and fine-tuning attacks. However, lacking in previous works is a clear presentation of the conditions for effective defence. We propose a set of conditions for effective defence against harmful fine-tuning in LLMs called "Immunization conditions," which help us understand how we would construct and measure future defences. Using this formal framework for defence, we offer a synthesis of different research directions that might be persued to prevent harmful fine-tuning attacks and provide a demonstration of how to use these conditions experimentally showing early results of using an adversarial loss to immunize LLama2-7b-chat.
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