Fiber Specklegram Sensors (FSS) are vital for environmental monitoring due to their high temperature sensitivity, but their complex data poses challenges for predictive models. This study introduces Prion-ViT, a prion-inspired Vision Transformer model, inspired by biological prion memory mechanisms, to improve long-term dependency modeling and temperature prediction accuracy using FSS data. Prion-ViT leverages a persistent memory state to retain and propagate key features across layers, reducing mean absolute error (MAE) to 0.71C and outperforming models like ResNet, Inception Net V2, and Standard Vision Transformers. This paper also discusses Explainable AI (XAI) techniques, providing a perspective on specklegrams through attention and saliency maps, which highlight key regions contributing to predictions
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