Endoscopic procedures are crucial for colorectal cancer diagnosis, and three-dimensional reconstruction of the environment for real-time novel-view synthesis can significantly enhance diagnosis. We present PR-ENDO, a framework that leverages 3D Gaussian Splatting within a physically based, relightable model tailored for the complex acquisition conditions in endoscopy, such as restricted camera rotations and strong view-dependent illumination. By exploiting the connection between the camera and light source, our approach introduces a relighting model to capture the intricate interactions between light and tissue using physically based rendering and MLP. Existing methods often produce artifacts and inconsistencies under these conditions, which PR-ENDO overcomes by incorporating a specialized diffuse MLP that utilizes light angles and normal vectors, achieving stable reconstructions even with limited training camera rotations. We benchmarked our framework using a publicly available dataset and a newly introduced dataset with wider camera rotations. Our methods demonstrated superior image quality compared to baseline approaches.
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