Enhancing LLM Generation with Knowledge Hypergraph for Evidence-Based Medicine

Evidence-based medicine (EBM) plays a crucial role in the application of large language models (LLMs) in healthcare, as it provides reliable support for medical decision-making processes. Although it benefits from current retrieval-augmented generation~(RAG) technologies, it still faces two significant challenges: the collection of dispersed evidence and the efficient organization of this evidence to support the complex queries necessary for EBM. To tackle these issues, we propose using LLMs to gather scattered evidence from multiple sources and present a knowledge hypergraph-based evidence management model to integrate these evidence while capturing intricate relationships. Furthermore, to better support complex queries, we have developed an Importance-Driven Evidence Prioritization (IDEP) algorithm that utilizes the LLM to generate multiple evidence features, each with an associated importance score, which are then used to rank the evidence and produce the final retrieval results. Experimental results from six datasets demonstrate that our approach outperforms existing RAG techniques in application domains of interest to EBM, such as medical quizzing, hallucination detection, and decision support. Testsets and the constructed knowledge graph can be accessed at \href{this https URL}{this https URL}.

@article{dou2025_2503.16530,
  title={ Enhancing LLM Generation with Knowledge Hypergraph for Evidence-Based Medicine },
  author={ Chengfeng Dou and Ying Zhang and Zhi Jin and Wenpin Jiao and Haiyan Zhao and Yongqiang Zhao and Zhengwei Tao },
  journal={arXiv preprint arXiv:2503.16530},
  year={ 2025 }
}