Graph Classification and Radiomics Signature for Identification of Tuberculous Meningitis

Introduction: Tuberculous meningitis (TBM) is a serious brain infection caused by Mycobacterium tuberculosis, characterized by inflammation of the meninges covering the brain and spinal cord. Diagnosis often requires invasive lumbar puncture (LP) and cerebrospinal fluid (CSF) analysis. Objectives: This study aims to classify TBM patients using T1-weighted (T1w) non-contrast Magnetic Resonance Imaging (MRI) scans. We hypothesize that specific brain regions, such as the interpeduncular cisterns, bone, and corpus callosum, contain visual markers that can non-invasively distinguish TBM patients from healthy controls. We propose a novel Pixel-array Graphs Classifier (PAG-Classifier) that leverages spatial relationships between neighbouring 3D pixels in a graph-based framework to extract significant features through eigen decomposition. These features are then used to train machine learning classifiers for effective patient classification. We validate our approach using a radiomics-based methodology, classifying TBM patients based on relevant radiomics features. Results: We utilized an internal dataset consisting of 52 scans, 32 from confirmed TBM patients based on mycobacteria detection in CSF, and 20 from healthy individuals. We achieved a 5-fold cross-validated average F1 score of 85.71% for cistern regions with our PAG-Classifier and 92.85% with the radiomics features classifier, surpassing current state-of-the-art benchmarks by 15% and 22%, respectively. However, bone and corpus callosum regions showed poor classification effectiveness, with average F1 scores below 50%. Conclusion: Our study suggests that algorithms like the PAG-Classifier serve as effective tools for non-invasive TBM analysis, particularly by targeting the interpeduncular cistern. Findings indicate that the bone and corpus callosum regions lack distinctive patterns for differentiation.

@article{agarwal2025_2504.00943,
  title={ Graph Classification and Radiomics Signature for Identification of Tuberculous Meningitis },
  author={ Snigdha Agarwal and Ganaraja V H and Neelam Sinha and Abhilasha Indoria and Netravathi M and Jitender Saini },
  journal={arXiv preprint arXiv:2504.00943},
  year={ 2025 }
}