Nuclear instance segmentation plays a vital role in disease diagnosis within digital pathology. However, limited labeled data in pathological images restricts the overall performance of nuclear instance segmentation. To tackle this challenge, we propose a novel data augmentation framework Instance Migration Diffusion Model (IM-Diffusion), IM-Diffusion designed to generate more varied pathological images by constructing diverse nuclear layouts and internuclear spatial relationships. In detail, we introduce a Nuclear Migration Module (NMM) which constructs diverse nuclear layouts by simulating the process of nuclear migration. Building on this, we further present an Internuclear-regions Inpainting Module (IIM) to generate diverse internuclear spatial relationships by structure-aware inpainting. On the basis of the above, IM-Diffusion generates more diverse pathological images with different layouts and internuclear spatial relationships, thereby facilitating downstream tasks. Evaluation on the CoNSeP and GLySAC datasets demonstrate that the images generated by IM-Diffusion effectively enhance overall instance segmentation performance. Code will be made public later.
View on arXiv@article{qi2025_2504.01577,
title={ Instance Migration Diffusion for Nuclear Instance Segmentation in Pathology },
author={ Lirui Qi and Hongliang He and Tong Wang and Siwei Feng and Guohong Fu },
journal={arXiv preprint arXiv:2504.01577},
year={ 2025 }
}