Heterogeneous network drug-target interaction prediction model based on graph wavelet transform and multi-level contrastive learning

Drug-target interaction (DTI) prediction is a core task in drug development and precision medicine in the biomedical field. However, traditional machine learning methods generally have the black box problem, which makes it difficult to reveal the deep correlation between the model decision mechanism and the interaction pattern between biological molecules. This study proposes a heterogeneous network drug target interaction prediction framework, integrating graph neural network and multi scale signal processing technology to construct a model with both efficient prediction and multi level interpretability. Its technical breakthroughs are mainly reflected in the following three dimensions:Local global feature collaborative perception module. Based on heterogeneous graph convolutional neural network (HGCN), a multi order neighbor aggregation strategy isthis http URLscale graph signal decomposition and biological interpretation module. A deep hierarchical node feature transform (GWT) architecture isthis http URLlearning combining multi dimensional perspectives and hierarchical representations. By comparing the learning models, the node representations from the two perspectives of HGCN and GWT are aligned and fused, so that the model can integrate multi dimensional information and improve the prediction robustness. Experimental results show that our framework shows excellent prediction performance on all datasets. This study provides a complete solution for drug target discovery from black box prediction to mechanism decoding, and its methodology has important reference value for modeling complex biomolecular interaction systems.

@article{dai2025_2504.20103,
  title={ Heterogeneous network drug-target interaction prediction model based on graph wavelet transform and multi-level contrastive learning },
  author={ Wenfeng Dai and Yanhong Wang and Shuai Yan and Qingzhi Yu and Xiang Cheng },
  journal={arXiv preprint arXiv:2504.20103},
  year={ 2025 }
}