This study conducts a comprehensive comparison of four neural network architectures: Convolutional Neural Network, Capsule Network, Convolutional Kolmogorov-Arnold Network, and the newly proposed Capsule-Convolutional Kolmogorov-Arnold Network. The proposed Capsule-ConvKAN architecture combines the dynamic routing and spatial hierarchy capabilities of Capsule Network with the flexible and interpretable function approximation of Convolutional Kolmogorov-Arnold Networks. This novel hybrid model was developed to improve feature representation and classification accuracy, particularly in challenging real-world biomedical image data. The architectures were evaluated on a histopathological image dataset, where Capsule-ConvKAN achieved the highest classification performance with an accuracy of 91.21%. The results demonstrate the potential of the newly introduced Capsule-ConvKAN in capturing spatial patterns, managing complex features, and addressing the limitations of traditional convolutional models in medical image classification.