Current multispectral object detection methods often retain extraneous background or noise during feature fusion, limiting perceptual performance. To address this, we propose an innovative feature fusion framework based on cross-modal feature contrastive and screening strategy, diverging from conventional approaches. The proposed method adaptively enhances salient structures by fusing object-aware complementary cross-modal features while suppressing shared background interference. Our solution centers on two novel, specially designed modules: the Mutual Feature Refinement Module (MFRM) and the Differential Feature Feedback Module (DFFM). The MFRM enhances intra- and inter-modal feature representations by modeling their relationships, thereby improving cross-modal alignment and discriminative power. Inspired by feedback differential amplifiers, the DFFM dynamically computes inter-modal differential features as guidance signals and feeds them back to the MFRM, enabling adaptive fusion of complementary information while suppressing common-mode noise across modalities. To enable robust feature learning, the MFRM and DFFM are integrated into a unified framework, which is formally formulated as an Iterative Relation-Map Differential Guided Feature Fusion mechanism, termed IRDFusion. IRDFusion enables high-quality cross-modal fusion by progressively amplifying salient relational signals through iterative feedback, while suppressing feature noise, leading to significant performance gains. In extensive experiments on FLIR, LLVIP and M $^3$ FD datasets, IRDFusion achieves state-of-the-art performance and consistently outperforms existing methods across diverse challenging scenarios, demonstrating its robustness and effectiveness. Code will be available atthis https URL.

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