A Mixture-of-Experts Framework with Log-Logistic Components for Survival Analysis on Histopathology Images

We propose a modular framework for predicting cancer specific survival from whole slide pathology images (WSIs). The method integrates four components: (i) Quantile Gated Patch Selection via quantile based thresholding to isolate prognostically informative tissue regions; (ii) Graph Guided Clustering using a k nearest neighbor graph to capture phenotype level heterogeneity through spatial and morphological coherence; (iii) Hierarchical Context Attention to learn intra and inter cluster interactions; and (iv) an Expert Driven Mixture of Log logistics framework to estimate complex survival distributions using Log logistics distributions. The model attains a concordance index of 0.644 on TCGA LUAD, 0.751 on TCGA KIRC, and 0.752 on TCGA BRCA respectively, outperforming existing state of the art approaches.